Reactivating PTEN to Impair Glioma Stem Cells by Inhibiting Cytosolic Iron-Sulfur Assembly

Medicine, Neurosurgery, Oncology, Life Sciences, Cell Biology, Biochemistry, Genetics,
PTEN   Glioma Stem Cells   Iron-Sulfur Clusters   Drug Combination   Desuccination  

Using the Suppression of Cytoplasmic Iron-Sulfur Cluster Assembly to Restore PTEN and Inhibit Glioma Stem Cells Background Glioblastoma (GBM) is one of the most lethal primary brain tumors. Glioma stem cells (GSCs) not only initiate and sustain the malignant phenotype but also enhance treatment resistance. Although PTEN frequently mutates in gliobl...