FUS/CircZEB1/miR-128-3p/LBH Feedback Loop Promotes Malignant Phenotype of GSCs via TNF-α Mediated NF-κB Signaling Pathway

Medicine, Neurology, Oncology, Life Sciences, Biochemistry, Immunology, Genetics,
Glioblastoma   CircZEB1   Glioma Stem Cells   Limb-Bud and Heart   NF-κB Signaling Pathway  

The Role of the Novel Circular RNA circZEB1 in the Malignant Phenotype of Glioblastoma Stem Cells and Its Molecular Mechanism Research Background Glioblastoma (GBM) is one of the most aggressive and fatal primary tumors in the central nervous system, with a very poor prognosis for patients. Even with surgery, radiotherapy, and chemotherapy, the ave...

Reactivating PTEN to Impair Glioma Stem Cells by Inhibiting Cytosolic Iron-Sulfur Assembly

Medicine, Neurosurgery, Oncology, Life Sciences, Cell Biology, Biochemistry, Genetics,
PTEN   Glioma Stem Cells   Iron-Sulfur Clusters   Drug Combination   Desuccination  

Using the Suppression of Cytoplasmic Iron-Sulfur Cluster Assembly to Restore PTEN and Inhibit Glioma Stem Cells Background Glioblastoma (GBM) is one of the most lethal primary brain tumors. Glioma stem cells (GSCs) not only initiate and sustain the malignant phenotype but also enhance treatment resistance. Although PTEN frequently mutates in gliobl...