Inhibition of p70 Ribosomal S6 Kinase (S6K1) Reduces Cortical Blood Flow in a Rat Model of Autism-Tuberous Sclerosis

Inhibition of p70 ribosomal S6 kinase (S6K1) Reduces Cerebral Cortical Blood Flow in Autism-Tuberous Sclerosis Rats: Research Report Background Tuberous Sclerosis Complex (TSC) is a genetic disorder caused by mutations in the TSC1 or TSC2 genes, primarily characterized by multiple benign tumors, including symptoms such as epilepsy, autism spectrum ...

Dentate Gyrus Morphogenesis is Regulated by an Autism Risk Gene Trio Function in Granule Cells

Research Background and Objectives Autism Spectrum Disorders (ASDs) are a group of highly heritable neurodevelopmental disorders, primarily characterized by abnormal social interactions, communication deficits, and restricted repetitive behaviors or interests. Previous studies have reported structural changes in brain regions including the hippocam...