JAK2/mTOR Inhibition Fails to Prevent Acute GVHD Despite Reduced Th1/Th17 Cells: Final Phase 2 Trial Results

Medicine, Hematology, Life Sciences, Immunology,
JAK2/mTOR inhibition   acute GVHD   Th1/Th17 cells   allogeneic hematopoietic cell transplantation   clinical trial   immunosuppression   cell differentiation  

Inhibition of JAK2/mTOR Fails to Effectively Prevent Acute Graft-versus-Host Disease (GVHD): Limitations of Targeting Th1/Th17 Cells In recent years, the role of systemic immunosuppressive therapies in preventing acute graft-versus-host disease (aGVHD) following allogeneic hematopoietic cell transplantation (alloHCT) has come under scrutiny. Th1 (T...

The Role of lncRNA-Mediated ceRNA Network in Penile Squamous Cell Carcinoma

Medicine, Urology, Oncology, Life Sciences, Immunology, Genetics,
long non-coding RNA   competing endogenous RNA network   penile squamous cell carcinoma   tumor microenvironment   immunosuppression  

The Role of lncRNA-Mediated ceRNA Network in Penile Squamous Cell Carcinoma Academic Background Penile Squamous Cell Carcinoma (PSCC) is a relatively rare but life-threatening malignancy that poses a significant health risk to men, particularly in developing countries. Despite advancements in medical diagnosis and treatment, the overall survival ra...

Coagulation Factor X Promotes Resistance to Androgen-Deprivation Therapy in Prostate Cancer

Medicine, Urology, Oncology, Life Sciences, Biochemistry, Immunology,
prostate cancer   androgen-deprivation therapy   coagulation factor X   immunosuppression   tumor microenvironment  

Study on the Role of Coagulation Factor X in Anti-androgen Resistance in Prostate Cancer Research Background Prostate cancer (PCa) is the second most common cancer in men worldwide and is one of the leading causes of cancer-related deaths. The occurrence and progression of prostate cancer are highly dependent on the androgen receptor (AR) signaling...

Effect of Immunosuppression in Risk of Developing Generalized Symptoms in Ocular Myasthenia Gravis

Medicine, Rheumatology and Immunology, Neurology, Ophthalmology, Life Sciences, Immunology,
immunosuppression   ocular myasthenia gravis   generalization   steroids   retrospective study  

The Effect of Immunosuppression on the Risk of Generalization in Ocular Myasthenia Gravis Background Ocular Myasthenia Gravis (OMG) is an early and localized manifestation of Myasthenia Gravis (MG), with many patients initially presenting with ocular symptoms such as fatigable ptosis and diplopia. Approximately 85% of MG patients initially exhibit ...

Single-cell atlas reveals the immunosuppressive microenvironment and Treg cells landscapes in recurrent glioblastoma

Medicine, Rheumatology and Immunology, Neurology, Neurosurgery, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology,
glioblastoma   tumor microenvironment   single-cell sequencing   Treg cells   cerebrospinal fluid   immunosuppression   tumor biomarkers  

Single-Cell Atlas Reveals Immunosuppressive Microenvironment and Treg Cell Distribution in Recurrent Glioblastoma Glioblastoma is the most aggressive brain tumor, with a very high recurrence rate and poor prognosis. Although many studies have explored the tumor microenvironment of this disease, the understanding of the immune microenvironment in re...

Mesenchymal Stromal Cells with Chimeric Antigen Receptors for Enhanced Immunosuppression

Medicine, Rheumatology and Immunology, Life Sciences, Cell Biology, Immunology, Humanities and Others,
mesenchymal stromal cells   chimeric antigen receptors   immunosuppression   graft-versus-host disease   cell therapy  

Mesenchymal Stromal Cells with Chimeric Antigen Receptors for Enhanced Immunosuppression Background Mesenchymal Stromal Cells (MSCs) are pluripotent cells found in almost all tissues and possess significant immunosuppressive and regenerative properties. These features make MSCs widely studied for the treatment of immune diseases and tissue regenera...