Alternative Lengthening of Telomere-Based Immortalization Renders H3G34R-Mutant Diffuse Hemispheric Glioma Hypersensitive to PARP Inhibitor Combination Regimens

Medicine, Neurology, Oncology,
alternative lengthening of telomeres   H3G34R mutation   diffuse hemispheric glioma   PARP inhibitors   DNA damage stress  

Background Introduction Diffuse Hemispheric Glioma (DHG) is a highly aggressive and poorly prognostic high-grade glioma, particularly prevalent in children and adolescents. The H3G34R/V mutation is one of the common genetic alterations in this type of tumor, often accompanied by the inactivation of the ATRX (Alpha-Thalassemia/Mental Retardation Syn...

Patterns of Genomic Instability in Ovarian Cancer Patients

Medicine, Obstetrics and Gynecology, Oncology, Life Sciences, Biochemistry, Genetics,
ovarian cancer   genomic instability   PARP inhibitors   homologous recombination deficiency   clinical trials   BRCA mutations   precision medicine  

Background and Research Question Ovarian cancer, as a fatal gynecological malignancy, has become the focus of recent studies, particularly on expanding the feasibility of targeted therapies. The introduction of poly(ADP-ribose) polymerase (PARP) inhibitors has marked a groundbreaking treatment option for ovarian cancer, especially for patients with...

Patient Assessment and Therapy Planning Based on Homologous Recombination Repair Deficiency

Medicine, Oncology, Life Sciences, Cell Biology, Genetics,
Homologous recombination repair deficiency   DNA damage response   Biomarker   PARP inhibitors   Gene mutations   Cancer therapy   Genomic scars  

Application of Homologous Recombination Deficiency (HRD) in Tumor Patient Assessment and Treatment Planning Background Homologous Recombination (HR) is an important mechanism for repairing DNA Double-Strand Breaks (DSBs). However, when key genes in the HR repair pathway are mutated or epigenetically inactivated, cells are unable to effectively repa...