Highly Efficient and Comprehensive Genome Editing Tool: A High-Performance Prime Editing Platform for Multiplexed Dropout Screening In the field of genome editing, Prime Editing has garnered significant attention for its precision and flexibility. This method allows for precise single-base substitutions and small insertions or deletions in the geno...

Precise Modeling of Mitochondrial Diseases: Research Based on Optimized Mitobes Academic Background Mitochondrial diseases are a group of genetic disorders caused by mutations in mitochondrial DNA (mtDNA), which affect cellular energy metabolism and lead to dysfunction in multiple organs. Mitochondrial DNA mutations can be homoplasmic (affecting al...

Report on the Academic Paper Paper Source The paper, titled “Modulation of TCR Stimulation and Pifithrin-α Improves the Genomic Safety Profile of CRISPR-Engineered Human T Cells,” was authored by Laurenz T. Ursch, Jule S. Müschen, Julia Ritter, and others from institutions such as the Technical University of Munich and the University of Freiburg Me...