The Maternal X Chromosome Affects Cognition and Brain Ageing in Female Mice

Medicine, Neurology, Life Sciences, Cell Biology, Genetics,
maternal X chromosome   cognitive function   brain ageing   female mice   genomic imprinting   hippocampus   CRISPR  

The Impact of the Maternal X Chromosome on Cognition and Brain Aging in Female Mice Background Introduction In mammals, female cells possess two X chromosomes, one from the mother (maternal X chromosome, Xm) and one from the father (paternal X chromosome, Xp). During embryonic development, one of the X chromosomes is randomly inactivated, a process...

Genome-aware annotation of CRISPR guides validates targets in variant cell lines and enhances discovery in screens

Medicine, Oncology, Life Sciences, Cell Biology, Bioengineering, Genetics,
CRISPR   genome annotation   bioinformatics   computational biology   software tool  

Genomic Medicine and Re-annotation of CRISPR Guides: Application and Validation of the EXORCISE Algorithm Academic Background The advent of CRISPR-Cas9 technology has revolutionized genetic screening, particularly in studying gene essentiality and chemo-genetic interactions. By designing guide RNAs (gRNAs) that target specific genes, the CRISPR-Cas...

Modulation of TCR Stimulation and Pifithrin-A Improves the Genomic Safety Profile of CRISPR-Engineered Human T Cells

Medicine, Oncology, Life Sciences, Cell Biology, Immunology, Genetics,
CRISPR   T cells   genomic safety   Pifithrin-A   TCR stimulation   chromosomal aberrations   gene editing  

Report on the Academic Paper Paper Source The paper, titled “Modulation of TCR Stimulation and Pifithrin-α Improves the Genomic Safety Profile of CRISPR-Engineered Human T Cells,” was authored by Laurenz T. Ursch, Jule S. Müschen, Julia Ritter, and others from institutions such as the Technical University of Munich and the University of Freiburg Me...