Glucagon Promotes Increased Hepatic Mitochondrial Oxidation and Pyruvate Carboxylase Flux in Humans with Fatty Liver Disease

Medicine, Hepatobiliary System, Basic Medical Sciences, Endocrinology, Gastroenterology, Life Sciences, Biochemistry,
glucagon   hepatic mitochondrial oxidation   pyruvate carboxylase   fatty liver   metabolic dysfunction  

Study on the Effect of Glucose Regulation on Hepatic Mitochondrial Oxidation and Pyruvate Carboxylase Flux in Patients with Fatty Liver Disease Research Background and Significance Metabolic-dysfunction-associated Steatotic Liver Disease (MASLD) has become one of the major challenges in global health in the 21st century. This condition is often acc...

Cytosolic Calcium Regulates Hepatic Mitochondrial Oxidation, Intrahepatic Lipolysis, and Gluconeogenesis via CaMKII Activation

Medicine, Hepatobiliary System, Life Sciences, Cell Biology, Biochemistry, Bioengineering,
cytosolic calcium   hepatic mitochondrial oxidation   CaMKII activation   lipolysis   gluconeogenesis  

Background Introduction In the field of cellular energy metabolism research, mitochondrial calcium ion ([Ca²⁺]mt) is considered an important node in regulating mitochondrial oxidative function. Its role mainly involves activating calcium-sensitive dehydrogenases in the tricarboxylic acid cycle (TCA), including isocitrate dehydrogenase (IDH) and α-k...