The Inflammatory Landscape of a Whole-Tissue Explant Model of Hidradenitis Suppurativa

Medicine, Life Sciences, Immunology,
inflammatory skin disease   explant model   hidradenitis suppurativa   immunology   inflammation  

Research Background Current Status and Challenges in Hidradenitis Suppurativa Research Hidradenitis Suppurativa (HS) is a relatively common and highly morbid inflammatory skin disease. It affects approximately 1% of the global population, disproportionately impacting women and marginalized groups. HS’s pathogenesis is complex, involving genetic, im...

mRNA-LNP Prime Boost Evolves Precursors Toward VRC01-Like Broadly Neutralizing Antibodies in Preclinical Humanized Mouse Models

Medicine, Infectious Diseases, Rheumatology and Immunology, Life Sciences, Immunology, Microbiology,
mRNA vaccines   broadly neutralizing antibodies   preclinical humanized mouse models   HIV   immunology   lipid nanoparticles  

Inducing and Optimizing VRC01-like Broadly Neutralizing Antibodies in Mouse Models with mRNA-LNP Background Introduction In recent years, the importance of acquiring broadly neutralizing antibodies (bnAbs) has been increasingly recognized in vaccine development, particularly in the field of HIV (Human Immunodeficiency Virus) vaccine research. The H...