Relative Quantification of Proteins and Post-Translational Modifications in Proteomic Experiments with Shared Peptides: A Weight-Based Approach

Life Sciences, Biochemistry, Bioengineering,
protein quantification   post-translational modifications   shared peptides   mass spectrometry   bioinformatics  

In proteomics research, mass spectrometry (MS) is widely used to analyze changes in protein abundance and structure. However, protein quantification faces a critical challenge: many proteins share the same peptides (shared peptides), meaning these peptides appear in the sequences of multiple proteins. Traditional methods typically rely solely on un...

Amyloid-β peptide signature associated with cerebral amyloid angiopathy in familial Alzheimer’s disease with APPdup and Down syndrome

Medicine, Medical Laboratory Science, Neurology, Life Sciences, Cell Biology, Biochemistry, Immunology,
Alzheimer’s disease   Down syndrome   Aβ peptides   cerebral amyloid angiopathy   mass spectrometry   neuropathology  

Background Introduction Alzheimer’s disease (AD) is an age-related neurodegenerative disease characterized by the death of neurons in the brain. Its main pathological features include extracellular β-amyloid plaques and intracellular neurofibrillary tangles (NFTs). β-amyloid plaques are primarily composed of aggregated Amyloid beta peptides (Aβ). A...