Plasma S100β as a Predictor for Pathology and Cognitive Decline in Alzheimer’s Disease Academic Background Alzheimer’s Disease (AD) is the most common form of dementia, characterized by the deposition of β-amyloid (Aβ) plaques and the aggregation of hyperphosphorylated microtubule-associated protein tau (tau). These pathological changes lead to gra...
Non-invasive MRI Study of Blood-Cerebrospinal Fluid Barrier Function in a Mouse Model of Alzheimer’s Disease Academic Background Alzheimer’s Disease (AD) is a common neurodegenerative disorder characterized by the accumulation of β-amyloid (Aβ) plaques and neurofibrillary tangles. Recent studies have increasingly shown that the Blood-Cerebrospinal ...
FBXL16: A New Regulator of Neuroinflammation and Cognition in Alzheimer’s Disease through Ubiquitination-Dependent Degradation of Amyloid Precursor Protein Academic Background Alzheimer’s Disease (AD) is an age-related neurodegenerative disorder characterized by progressive cognitive decline. With the global aging population, the incidence of neuro...
Cascading Pattern in Genetic Risk Research for Alzheimer’s Disease Background and Research Motivation Alzheimer’s disease (AD) is a slowly progressing neurodegenerative disorder characterized by the accumulation of two pathological features: amyloid plaques and phosphorylated tau neurofibrillary tangles. These pathological features typically exist ...
CRISPR-Cas-Based Epigenome Editing in Alzheimer’s Disease: Engineered Exosomes with a Photoinducible Protein Delivery System Background Alzheimer’s Disease (AD) is a common neurodegenerative disorder characterized by progressive decline in cognitive function and memory, with currently limited treatment options. Genome editing technologies, such as ...
Astaxanthin Protects Hippocampal Neurons Against Memory Impairment Caused by Vascular Dementia in Rats Background Introduction Vascular Dementia (VAD) is a progressive cognitive disorder caused by cerebrovascular disease leading to cognitive decline. Current research shows that chronic cerebral hypoperfusion (CCH) and insufficient blood supply are ...
Study on the Improvement of Cognitive Function in ICV-STZ-Induced Alzheimer’s Disease Mouse Model by Lycium Barbarum Polysaccharides Research Background Alzheimer’s disease (AD) is the most common neurodegenerative disease of the central nervous system, characterized by progressive cognitive impairment, memory loss, personality changes, and emotion...
Original Title: 《Associations of CSF BACE1 with Amyloid Pathology, Neurodegeneration, and Cognition in Alzheimer’s Disease》 Background and Research Purpose Alzheimer’s Disease (AD) is a leading cause of dementia in the elderly, characterized by the accumulation of β-amyloid protein (Aβ) plaques in the brain. Beta-site APP cleaving enzyme 1 (BACE1) ...
Background Introduction Alzheimer’s disease (AD) is an age-related neurodegenerative disease characterized by the death of neurons in the brain. Its main pathological features include extracellular β-amyloid plaques and intracellular neurofibrillary tangles (NFTs). β-amyloid plaques are primarily composed of aggregated Amyloid beta peptides (Aβ). A...
Unique Patterns of Glycosylation in Plaques and Microglia in Alzheimer’s Disease Research Background Alzheimer’s disease (AD) is the most common form of dementia and a devastating neurodegenerative disorder. AD is characterized by two pathological features: extracellular β-amyloid (Aβ) plaques and intracellular phosphorylated Tau neurofibrillary ta...