Mapping Functional to Morphological Variation Reveals the Basis of Regional Extracellular Matrix Subversion and Nerve Invasion in Pancreatic Cancer

Medicine, Hepatobiliary System, Basic Medical Sciences, Oncology, Life Sciences, Cell Biology, Biochemistry,
pancreatic cancer   extracellular matrix   nerve invasion   morphological variation   transcriptional programs   tumor heterogeneity  

The Biological Basis of Regional ECM Breakdown and Nerve Invasion in Pancreatic Cancer Background Pancreatic Ductal Adenocarcinoma (PDAC) is one of the most aggressive types of cancer, typically associated with a highly fibrotic stroma, which can account for about 90% of the tumor mass. Although morphological heterogeneity is not addressed in routi...