Mapping Functional to Morphological Variation Reveals the Basis of Regional Extracellular Matrix Subversion and Nerve Invasion in Pancreatic Cancer

Medicine, Hepatobiliary System, Basic Medical Sciences, Oncology, Life Sciences, Cell Biology, Biochemistry,
pancreatic cancer   extracellular matrix   nerve invasion   morphological variation   transcriptional programs   tumor heterogeneity  

The Biological Basis of Regional ECM Breakdown and Nerve Invasion in Pancreatic Cancer Background Pancreatic Ductal Adenocarcinoma (PDAC) is one of the most aggressive types of cancer, typically associated with a highly fibrotic stroma, which can account for about 90% of the tumor mass. Although morphological heterogeneity is not addressed in routi...

Physical Immune Escape: Weakened Mechanical Communication Leads to Escape of Metastatic Colorectal Carcinoma Cells from Macrophages

Physical Immune Escape: Weakened Mechanical Communication Leads to Escape of Metastatic Colorectal Carcinoma Cells from Macrophages

Life Sciences, Cell Biology, Immunology, Biophysics,
mechanical signals   immune escape   extracellular matrix   cancer metastasis   macrophages  

Physical Immunoevasion: Attenuated Mechanical Communication Facilitates Metastatic Colorectal Cancer Cells to Evade Macrophage Attack Background Introduction Cancer metastasis is a complex and daunting challenge, with metastatic cancer cells capable of evading immune cell attacks, breaching the extracellular matrix (ECM), and migrating to other sit...