Clonal Lineage Tracing with Recordable Barcodes Reveals Migration Histories of Metastatic Prostate Cancer

Medicine, Geriatrics, Urology, Oncology,
clonal lineage tracing   metastatic prostate cancer   barcodes   tumor evolution   mouse model   tumor heterogeneity  

title: “Utilizing Clonal Lineage Tracing with Recordable Barcodes Unveils the Migration History of Prostate Cancer Metastasis” author: Ryan N. Serio, Armin Scheben, *Billy Lu, *Domenic V. Gargiulo, Lucrezia Patruno, Caroline L. Buckholtz, Ryan J. Chaffee, Megan C. Jibilian, Steven G. Persaud, Stephen J. Staklinski, Rebecca Hassett, Lise M. Brault, ...

Representation of Genomic Intratumor Heterogeneity in Multi-Region Non-Small Cell Lung Cancer Patient-Derived Xenograft Models

Medicine, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology, Genetics,
non-small cell lung cancer   xenograft models   tumor heterogeneity   genomic evolution   multi-region sampling  

Manifestations of Genomic-Level Intratumoral Tumor Heterogeneity in Multi-Region Patient-Derived Xenograft Models of Non-Small Cell Lung Cancer Academic Background and Research Motivation Patient-Derived Xenograft (PDX) models are widely used in cancer research. PDX models are established by transplanting human tumors into immunodeficient mice. The...

Mapping Functional to Morphological Variation Reveals the Basis of Regional Extracellular Matrix Subversion and Nerve Invasion in Pancreatic Cancer

Medicine, Hepatobiliary System, Basic Medical Sciences, Oncology, Life Sciences, Cell Biology, Biochemistry,
pancreatic cancer   extracellular matrix   nerve invasion   morphological variation   transcriptional programs   tumor heterogeneity  

The Biological Basis of Regional ECM Breakdown and Nerve Invasion in Pancreatic Cancer Background Pancreatic Ductal Adenocarcinoma (PDAC) is one of the most aggressive types of cancer, typically associated with a highly fibrotic stroma, which can account for about 90% of the tumor mass. Although morphological heterogeneity is not addressed in routi...