Evaluation of Neuroprotective Effect of Gut Microbe in Parkinson's Disease: An In Silico and In Vivo Approach

Medicine, Neurology, Life Sciences, Biochemistry, Immunology, Microbiology,
α-synuclein   gut microbes   metabolites   protein-protein interaction   therapeutic agent   parkinsonian mice model  

Study on the Protective Effects of Medicinal Microorganisms on Parkinson’s Disease Background Introduction Parkinson’s Disease (PD) is a progressive neurodegenerative disorder characterized by the death of dopaminergic neurons in the substantia nigra region of the brain. The aggregation of α-synuclein is a crucial factor in the pathogenesis of Park...

Predicting Drug-Target Affinity by Learning Protein Knowledge from Biological Networks

Information Science, Computer Science, Artificial Intelligence, Life Sciences, Biochemistry, Bioengineering, Biophysics,
drug-target affinity   variational graph autoencoders   graph convolutional network   protein-protein interaction  

Predicting Drug-Target Affinity Based on Learning Protein Knowledge from Biological Networks Background The prediction of drug-target affinity (DTA) plays a crucial role in drug discovery. Efficient and accurate DTA prediction can significantly reduce the time and economic costs of new drug development. In recent years, the explosive development of...