Catch Bonds Nonlinearly Control CD8 Cooperation to Shape T Cell Specificity

Life Sciences, Cell Biology, Bioengineering, Immunology, Biophysics,
T-cell receptors   mechanical force   CD8 cooperation   specificity   cross-reactivity   immunotherapy   kinetics  

T cell receptors (TCRs) play a crucial role in the immune system by recognizing antigen peptides presented by major histocompatibility complexes (MHCs), thereby initiating immune responses against pathogens and tumor cells. However, the specificity of TCRs—their ability to distinguish self-antigens from non-self antigens—is central to the effective...

Validation of Laboratory Risk Indicator for Necrotizing Fasciitis (LRINEC) Score and Establishment of Novel Score in Japanese Patients with Necrotizing Fasciitis (J-LRINEC Score)

Medicine, Infectious Diseases,
necrotizing fasciitis   LRINEC score   Japanese patients   sensitivity   specificity   skin infection   J-LRINEC  

A Report on the Validation of the Laboratory Risk Indicator for Necrotizing Fasciitis (LRINEC) Score and the Establishment of a Novel Score (J-LRINEC) in Japanese Patients Academic Background Necrotizing fasciitis (NF) and cellulitis are two common skin infectious diseases. Although they share some similarities in clinical manifestations, their sev...