T cell receptors (TCRs) play a crucial role in the immune system by recognizing antigen peptides presented by major histocompatibility complexes (MHCs), thereby initiating immune responses against pathogens and tumor cells. However, the specificity of TCRs—their ability to distinguish self-antigens from non-self antigens—is central to the effective...
PD-L1 in Tumor-Derived Extracellular Vesicles Promotes T Cell Senescence through Lipid Metabolism Reprogramming Academic Background In recent years, immunotherapy has shown great promise in cancer treatment, particularly in checkpoint blockade therapies targeting PD-1/PD-L1 (programmed cell death protein 1 and its ligand) and CTLA-4 (cytotoxic T-ly...
Study on Reducing Toxicity of CAR-T Cell Therapy for Solid Tumors Academic Background Chimeric antigen receptor T-cell (CAR-T) therapy has made significant progress in treating hematologic malignancies, but its application in solid tumors faces major challenges. Solid tumors often lack tumor-specific antigens (TSAs), and CAR-T cells may attack norm...
Cancer Cells Evade Immune Cell-Induced Ferroptosis via Fatty Acid Binding Protein 7 Background Introduction Cancer creates an immunosuppressive environment that hinders immune responses, allowing tumors to grow and resist treatment. The immune system combats this by inducing ferroptosis in tumor cells through CD8+ T cells. Ferroptosis is a type of ...
Stochastic Modeling of Single-Cell Gene Expression Adaptation Reveals Non-Genomic Contribution to Tumor Subclone Evolution Academic Background Cancer is a complex disease whose progression is driven by the evolution of cells that are selected through adaptive advantages for growth. Traditionally, cancer evolution research has focused primarily on g...
Choline Phosphate-Based Antigen Capture Strategy Boosts In Situ Tumor Vaccine Research: A Novel Immunotherapy Approach In the field of cancer immunotherapy, in situ tumor vaccines have garnered significant attention for their ability to harness a patient’s immune system to target tumors. However, challenges remain in their clinical application. To ...
Using Liposomal Doxorubicin Neoadjuvant Chemotherapy to Enhance Immune Protection of Tumor Membrane Antigen-Based Nanovaccine Background and Significance Surgical resection remains the primary treatment for solid tumors, but postoperative tumor recurrence and metastasis continue to be major challenges. A promising emerging strategy in personalized ...
Phenotypic Plasticity of TREM1+ Mono-Macrophages Mediated by Radiotherapy Combined with Immunochemotherapy in Locally Advanced Rectal Cancer: A Comprehensive Multi-Omics Study Background Introduction Rectal cancer is the second leading cause of cancer-related deaths worldwide, accounting for one-third of all colorectal cancer cases. While surgical ...
Microglia and Macrophages in Glioblastoma Academic Background Glioblastoma (GBM) is the most common primary malignant tumor of the central nervous system, characterized by high invasiveness and lethality. Despite standard treatments such as surgery, chemotherapy, and radiotherapy, the survival rate of patients remains extremely limited, with a medi...
Discovery of a New Immunotherapy Target for Ewing Sarcoma Background Introduction Ewing sarcoma (Ewing’s sarcoma, EWS) is a common pediatric bone cancer, accounting for approximately 2% of childhood cancers. Despite significant advances in immune checkpoint inhibitors (ICIs) and CAR-T cell therapy in various cancers, their efficacy in Ewing sarcoma...