Structural Insights into Spliceosome Fidelity: DHX35–GPATCH1-Mediated Rejection of Aberrant Splicing Substrates

Life Sciences, Cell Biology, Biochemistry, Genetics,
spliceosome   DHX35   GPATCH1   splicing fidelity   cryo-electron microscopy   aberrant splicing substrates   RNA helicase  

Academic Background Introduction The spliceosome is a highly dynamic macromolecular complex responsible for the precise excision of introns from pre-mRNA. Although recent advances in cryo-electron microscopy (cryo-EM) have provided a comprehensive structural understanding of the stepwise assembly, catalytic splicing, and final disassembly of the sp...

Ferroptosis Triggered by Spliceosomal GTPase EFTUD2 Deficiency Leads to Purkinje Cell Degeneration

Medicine, Basic Medical Sciences, Neurology, Life Sciences, Cell Biology, Biochemistry, Genetics,
spliceosome   EFTUD2   ferroptosis   Purkinje cells   neurodegeneration   cerebellar development  

Depletion of EFTUD2 Triggers Ferroptosis-Induced Degeneration of Cerebellar Purkinje Cells Background and Motivation The cerebellum plays a crucial role in motor coordination and higher cognitive functions, with the health of cerebellar Purkinje cells (PCs) being essential for maintaining cerebellar function. Gene regulation based on alternative sp...