GYS1 Antisense Therapy Prevents Disease-Driving Aggregates and Epileptiform Discharges in a Lafora Disease Mouse Model

Medicine, Basic Medical Sciences, Neurology, Life Sciences, Cell Biology, Biochemistry, Immunology,
GYS1   antisense oligonucleotide   epilepsy   Lafora disease   glycogen synthesis   neuroinflammation   neurodegeneration  

GYS1 Antisense Therapy Inhibits Pathogenic Aggregates and Epileptiform Discharges in a Mouse Model of Lafora Disease Background and Objectives Lafora disease (LD) is a devastating autosomal recessive genetic disorder characterized by epilepsy and rapidly progressive dementia in adolescence. The disease primarily involves mutations in the EPM2A or E...

Gut-Induced Alpha-Synuclein and Tau Propagation Initiate Parkinson’s and Alzheimer’s Disease Co-Pathology and Behavior Impairments

Medicine, Neurology, Gastroenterology, Medical Imaging, Life Sciences, Cell Biology,
alpha-synuclein   tau protein   Parkinson's disease   Alzheimer's disease   behavioral impairments   gut-brain axis   neurodegeneration  

Gastrointestinal-Induced Spread of α-Synuclein and Tau Proteins Triggers Comorbid Pathology and Behavioral Impairments in Parkinson’s and Alzheimer’s Diseases Background Parkinson’s Disease (PD) and Alzheimer’s Disease (AD) are two common neurodegenerative disorders, caused by the aggregation of α-synuclein (a-syn) and Tau protein in the brain, res...

Ferroptosis Triggered by Spliceosomal GTPase EFTUD2 Deficiency Leads to Purkinje Cell Degeneration

Medicine, Basic Medical Sciences, Neurology, Life Sciences, Cell Biology, Biochemistry, Genetics,
spliceosome   EFTUD2   ferroptosis   Purkinje cells   neurodegeneration   cerebellar development  

Depletion of EFTUD2 Triggers Ferroptosis-Induced Degeneration of Cerebellar Purkinje Cells Background and Motivation The cerebellum plays a crucial role in motor coordination and higher cognitive functions, with the health of cerebellar Purkinje cells (PCs) being essential for maintaining cerebellar function. Gene regulation based on alternative sp...

Lycium Barbarum Polysaccharides Improves Cognitive Functions in ICV-STZ-Induced Alzheimer’s Disease Mice Model by Improving the Synaptic Structural Plasticity and Regulating IRS1/PI3K/AKT Signaling Pathway

Medicine, Medical Laboratory Science, Geriatrics, Neurology, Life Sciences, Biochemistry, Bioengineering, Immunology,
Alzheimer’s disease   ICV-STZ   insulin resistance   neurodegeneration   synapse  

Study on the Improvement of Cognitive Function in ICV-STZ-Induced Alzheimer’s Disease Mouse Model by Lycium Barbarum Polysaccharides Research Background Alzheimer’s disease (AD) is the most common neurodegenerative disease of the central nervous system, characterized by progressive cognitive impairment, memory loss, personality changes, and emotion...

Perioperative levels of IL8 and IL18, but not IL6, are associated with nucleus basalis magnocellularis atrophy three months after surgery

Medicine, Rheumatology and Immunology, Basic Medical Sciences, Medical Laboratory Science, Geriatrics, Neurology, Medical Imaging,
nucleus basalis magnocellularis   acetylcholine   interleukins   surgery   atrophy   neurodegeneration  

Association Study of Perioperative IL8 and IL18 Levels with Brain Basal Ganglia Atrophy Three Months After Surgery Background In recent years, an increasing number of studies have shown that surgical procedures may accelerate brain atrophy. Meanwhile, the relationship between systemic inflammation and neurodegenerative diseases has also received co...

Associations of CSF BACE1 with Amyloid Pathology, Neurodegeneration, and Cognition in Alzheimer’s Disease

Medicine, Basic Medical Sciences, Medical Laboratory Science, Neurology, Medical Imaging, Life Sciences,
Alzheimer’s disease   BACE1   PET imaging   neurodegeneration  

Original Title: 《Associations of CSF BACE1 with Amyloid Pathology, Neurodegeneration, and Cognition in Alzheimer’s Disease》 Background and Research Purpose Alzheimer’s Disease (AD) is a leading cause of dementia in the elderly, characterized by the accumulation of β-amyloid protein (Aβ) plaques in the brain. Beta-site APP cleaving enzyme 1 (BACE1) ...

p-tau217 correlates with neurodegeneration in Alzheimer’s disease, and targeting p-tau217 with immunotherapy ameliorates murine tauopathy

Medicine, Basic Medical Sciences, Neurology, Life Sciences, Biochemistry,
p-tau217   Alzheimer’s disease   neurodegeneration   immunotherapy   tau protein   brain atrophy   cognitive impairment  

Correlation between p-tau217 and Alzheimer’s Disease Neurodegeneration and the Ameliorative Effects of Targeting p-tau217 Immunotherapy in Mouse Tauopathy Introduction Neuron loss is a core issue in Alzheimer’s Disease (AD). However, to date, no therapy can halt the neurodegenerative changes associated with AD. Tau is a microtubule-associated prote...

Messenger RNA transport on lysosomal vesicles maintains axonal mitochondrial homeostasis and prevents axonal degeneration

Messenger RNA transport on lysosomal vesicles maintains axonal mitochondrial homeostasis and prevents axonal degeneration

Medicine, Basic Medical Sciences, Neurology, Life Sciences, Cell Biology, Biochemistry, Genetics,
messenger RNA   lysosomal vesicles   axonal mitochondria   neurodegeneration   RNA granules  

This study utilized induced pluripotent stem cell (iPSC)-derived neurons to investigate the critical role of lysosome-related vesicles in axonal mRNA transport and mitochondrial homeostasis maintenance. By knocking out BORC subunits (borcs5 or borcs7) to block the entry of lysosome-related vesicles into axons, researchers found that this led to a s...