GSDME-mediated pyroptosis contributes to chemotherapy-induced platelet hyperactivity and thrombotic potential

Background Introduction Chemotherapy has long been a cornerstone of cancer treatment but is accompanied by significant side effects. Among cancer patients receiving platinum-based chemotherapy drugs (e.g., cisplatin), the incidence of thromboembolic events significantly increases, including pulmonary embolism, cerebrovascular incidents, angina, and...

Delayed Plasma Kallikrein Inhibition Fosters Post-Stroke Recovery by Reducing Thrombo-Inflammation

Delayed Inhibition of Plasma Kallikrein Promotes Stroke Recovery: By Reducing Thromboinflammation Academic Background Stroke is a common neurovascular event affecting over 60 million patients worldwide annually. Current treatments for cerebral ischemia are limited to thrombolysis and mechanical thrombectomy, which are constrained by the feasibility...