Determining Risk Features for Medulloblastoma in the Molecular Era

Medicine, Pediatrics, Neurology, Oncology,
medulloblastoma   molecular classification   risk stratification   radiation therapy   methylation profiling   chemotherapy   survival rate  

Advances in Risk Stratification and Treatment Strategies for Medulloblastoma Background Medulloblastoma is a common malignant brain tumor in children, with significant differences in treatment and prognosis depending on its molecular subtypes. In recent years, advances in molecular biology have revealed that medulloblastoma can be further divided i...

GSDME-mediated pyroptosis contributes to chemotherapy-induced platelet hyperactivity and thrombotic potential

Medicine, Hematology, Life Sciences, Cell Biology, Biochemistry,
platelets   pyroptosis   chemotherapy   thrombosis   GSDME   caspase-3   membrane pore formation  

Background Introduction Chemotherapy has long been a cornerstone of cancer treatment but is accompanied by significant side effects. Among cancer patients receiving platinum-based chemotherapy drugs (e.g., cisplatin), the incidence of thromboembolic events significantly increases, including pulmonary embolism, cerebrovascular incidents, angina, and...

Circulating Tumor DNA-Based Stratification Strategy for Chemotherapy Plus PD-1 Inhibitor in Advanced Non-Small-Cell Lung Cancer

Medicine, Medical Laboratory Science, Oncology, Life Sciences, Immunology,
circulating tumor DNA   chemotherapy   PD-1 inhibitor   non-small-cell lung cancer   personalized treatment  

Exploration of a Chemotherapy and PD-1 Inhibitor Personalized Stratification Strategy Based on Circulating Tumor DNA in Advanced Non-Small Cell Lung Cancer Background and Significance of the Study Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related deaths globally. In the treatment of advanced NSCLC, the combination of immune ...

Temporal Changes in Treatment and Late Mortality and Morbidity in Adult Survivors of Childhood Glioma: A Report from the Childhood Cancer Survivor Study

Temporal Changes in Treatment and Late Mortality and Morbidity in Adult Survivors of Childhood Glioma: A Report from the Childhood Cancer Survivor Study

Medicine, Pediatrics, Neurosurgery, Oncology,
childhood glioma   late mortality   morbidity   radiation therapy   chemotherapy  

This is a long-term outcome study on survivors of pediatric glioma. The main purpose of the study was to evaluate the impact of changes in treatment approaches for pediatric glioma over the past few decades on long-term mortality, chronic health conditions, and subsequent tumor risk among survivors. Background: In the past, treatment for pediatric ...