Comprehensive Assessment of TDP-43 Neuropathology Data in the National Alzheimer’s Coordinating Center Database

Medicine, Medical Laboratory Science, Geriatrics, Neurology,
TDP-43   Limbic Predominant Age-Related TDP-43 Encephalopathy Neuropathologic Change   Frontotemporal Lobar Degeneration   Amyotrophic Lateral Sclerosis   Hippocampal Sclerosis of Aging   Dementia   Alzheimer’s Disease  

Research Report Titled “Comprehensive Evaluation of TDP-43 Neuropathology Data in the National Alzheimer’s Coordinating Center Database” Research Background TDP-43 proteinopathy is a significant neuropathological feature in frontotemporal lobar degeneration (FTLD-TDP), amyotrophic lateral sclerosis (ALS-TDP), and age-related limbic TDP-43 encephalo...

Abundant Transcriptomic Alterations in the Human Cerebellum of Patients with a C9orf72 Repeat Expansion

Medicine, Medical Laboratory Science, Neurology, Life Sciences, Cell Biology, Biochemistry, Genetics,
C9orf72   Amyotrophic Lateral Sclerosis   Frontotemporal Lobar Degeneration   Transcriptomics   Cryptic Exons  

Research Background In the field of neuroscience, amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) are two highly heterogeneous neurodegenerative diseases. Studies indicate that non-coding hexanucleotide repeat expansions in the c9orf72 gene are the most common genetic causes of these diseases. However, the specific ...