Aberrant Splicing in Huntington’s Disease Accompanies Disrupted TDP-43 Activity and Altered m6A RNA Modification

Medicine, Neurology, Life Sciences, Cell Biology, Genetics,
Huntington’s Disease   TDP-43   m6A RNA modification   aberrant splicing   neurodegenerative disorder  

Aberrant Splicing in Huntington’s Disease Accompanies Disrupted TDP-43 Activity and Altered m6A RNA Modification Academic Background Huntington’s disease (HD) is an autosomal dominant neurodegenerative disorder characterized by motor, cognitive, and psychiatric symptoms. The disease is caused by a CAG repeat expansion in the HTT gene, leading to ab...

Comprehensive Assessment of TDP-43 Neuropathology Data in the National Alzheimer’s Coordinating Center Database

Medicine, Medical Laboratory Science, Geriatrics, Neurology,
TDP-43   Limbic Predominant Age-Related TDP-43 Encephalopathy Neuropathologic Change   Frontotemporal Lobar Degeneration   Amyotrophic Lateral Sclerosis   Hippocampal Sclerosis of Aging   Dementia   Alzheimer’s Disease  

Research Report Titled “Comprehensive Evaluation of TDP-43 Neuropathology Data in the National Alzheimer’s Coordinating Center Database” Research Background TDP-43 proteinopathy is a significant neuropathological feature in frontotemporal lobar degeneration (FTLD-TDP), amyotrophic lateral sclerosis (ALS-TDP), and age-related limbic TDP-43 encephalo...

Annexin A11 Aggregation in FTLD-TDP Type C and Related Neurodegenerative Disease Proteinopathies

Medicine, Neurology, Life Sciences, Cell Biology, Biochemistry, Immunology,
neurodegenerative disease   TDP-43   FTLD-TDP   ALS   Annexin A11  

Study on Annexin A11 Aggregation and TDP-43 Proteinopathies in Neurodegenerative Diseases In this research report published in Acta Neuropathologica, researchers led by John L. Robinson from the University of Pennsylvania investigate the aggregation phenomena of Annexin A11 in neurodegenerative diseases, particularly in FTLD-TDP Type C, which is as...