Abundant Transcriptomic Alterations in the Human Cerebellum of Patients with a C9orf72 Repeat Expansion

Medicine, Medical Laboratory Science, Neurology, Life Sciences, Cell Biology, Biochemistry, Genetics,
C9orf72   Amyotrophic Lateral Sclerosis   Frontotemporal Lobar Degeneration   Transcriptomics   Cryptic Exons  

Research Background In the field of neuroscience, amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) are two highly heterogeneous neurodegenerative diseases. Studies indicate that non-coding hexanucleotide repeat expansions in the c9orf72 gene are the most common genetic causes of these diseases. However, the specific ...

Transcriptomic Profiling of Primary Prostate Cancers and Nonlocalized Disease on Prostate-Specific Membrane Antigen PET/CT: A Multicenter Retrospective Study

Medicine, Medical Laboratory Science, Urology, Oncology,
Prostate Cancer   Transcriptomics   Prostate-Specific Membrane Antigen   PET/CT   Genomic Classifier   Multicenter   Retrospective Study  

Transcriptomic Analysis of Prostate Cancer Patients: A Study on Nonlocalized Disease Based on Prostate-Specific Membrane Antigen Positron Emission Tomography/Computed Tomography Academic Background Prostate cancer is a common male malignancy, and its diagnosis and treatment are crucial to patient prognosis. Transcriptomic analysis is a technique us...

Cortical Gene Expression Architecture links Healthy Neurodevelopment to the Imaging, Transcriptomics and Genetics of Autism and Schizophrenia

Medicine, Psychiatry, Neurology, Life Sciences,
Cortical Gene Expression   Neurodevelopment   Autism   Schizophrenia   Imaging   Transcriptomics   Genetics  

Research Report: The Connection Between Cortical Gene Expression and Neurodevelopmental Disorders Research Background The anatomical and functional organization of the human brain is the result of the coordinated expression of numerous genes. It has been found that the first principal component (c1) of cortical gene expression plays a significant r...