Network-Wide Risk Convergence in Gene Co-Expression Identifies Reproducible Genetic Hubs of Schizophrenia Risk

Medicine, Psychiatry, Life Sciences, Biochemistry, Genetics,
gene co-expression   schizophrenia   genetic risk   neurons   GWAS   genome-wide association  

The Genetic Network Aggregation Mechanism for Schizophrenia Risk — Latest Research Interpretation from the Journal “Neuron” In recent years, genetic research on schizophrenia (SCZ) has made significant progress, particularly driven by genome-wide association studies (GWAS), revealing a large number of genetic variants associated with the disease. H...

Alteration of Gene Expression and Protein Solubility of the PI5-Phosphatase SHIP2 are Correlated with Alzheimer’s Disease Pathology Progression

Medicine, Basic Medical Sciences, Neurology, Life Sciences, Cell Biology, Biochemistry, Immunology, Genetics,
Alzheimer’s Disease   SHIP2   INPPL1   EGFR   Tau   Amyloid β   GWAS   CSF pTau  

Changes in Gene Expression and Protein Insolubility in Alzheimer’s Disease Progression Background Introduction As the most common type of dementia, Alzheimer’s Disease (AD) is well-known for its two main neuropathological features: amyloid plaques and neurofibrillary tangles (NFTs). Amyloid plaques consist of β-amyloid (Aβ) peptide segments generat...