Dopamine Receptors D1, D2, and D4 Modulate Electrical Synapses and Excitability in the Thalamic Reticular Nucleus

Medicine, Neurology, Life Sciences,
dopamine   electrical synapses   thalamic reticular nucleus   excitability   neurons   signal transduction   receptor subtypes  

Modulation of Electrical Synapses and Excitability by Dopamine Receptors in the Thalamic Reticular Nucleus Academic Background The Thalamic Reticular Nucleus (TRN) is a thin shell of γ-aminobutyric acid (GABA)ergic inhibitory neurons in the thalamus. These neurons are coupled via gap junctions and regulate the transmission of sensory information fr...

Increased Robustness and Adaptation to Simultaneous Temperature and Elevated Extracellular Potassium in the Pyloric Rhythm of the Crab, Cancer Borealis

Medicine, Neurology, Life Sciences,
crab   pyloric rhythm   high temperature   elevated potassium   adaptation   robustness   neurons  

Increased Robustness and Adaptation of the Crab Pyloric Rhythm to Simultaneous Temperature and Elevated Extracellular Potassium Academic Background In nature, animals often face multiple simultaneous environmental perturbations, which may include temperature fluctuations, pH variations, salinity changes, and alterations in extracellular potassium c...

Network-Wide Risk Convergence in Gene Co-Expression Identifies Reproducible Genetic Hubs of Schizophrenia Risk

Medicine, Psychiatry, Life Sciences, Biochemistry, Genetics,
gene co-expression   schizophrenia   genetic risk   neurons   GWAS   genome-wide association  

The Genetic Network Aggregation Mechanism for Schizophrenia Risk — Latest Research Interpretation from the Journal “Neuron” In recent years, genetic research on schizophrenia (SCZ) has made significant progress, particularly driven by genome-wide association studies (GWAS), revealing a large number of genetic variants associated with the disease. H...

Integration and Competition Between Space and Time in the Hippocampus

Medicine, Neurology, Life Sciences, Biochemistry, Biophysics,
hippocampus   space   time   neurons   memory  

A Review on the Mechanisms of Spatial and Temporal Integration and Competition in the Hippocampus Research Background and Significance In the human and animal brain, space and time comprise the primary dimensions of episodic memory, playing a crucial role in encoding information such as event sequences, locations, and durations. It has long been fo...

Single-Nucleus Sequencing Reveals Enriched Expression of Genetic Risk Factors in ALS-Sensitive Neurons

Medicine, Basic Medical Sciences, Geriatrics, Neurology, Life Sciences, Biochemistry, Genetics,
single-nucleus sequencing   ALS   neurons   genetic risk factors   transcriptomics  

Publication of a New Study on ALS Neurodegeneration in 《Nature Aging》 Throughout human history, numerous mysterious diseases have posed significant challenges for scientific research. Among these, Amyotrophic Lateral Sclerosis (ALS), a progressive neurodegenerative disease, is known for the gradual loss of muscle function and disability it causes. ...

Neuritogenic Glycosaminoglycan Hydrogels Promote Functional Recovery After Severe Traumatic Brain Injury

Chemistry, Polymer Chemistry, Medicinal Chemistry, Materials Science, Organic Polymeric Materials, Medicine, Neurology, Life Sciences, Bioengineering,
neuritogenic   glycosaminoglycan   hydrogel   traumatic brain injury   functional recovery   cell adhesion   neurons  

Neuritogenic Glycosaminoglycan Hydrogels Promote Functional Recovery After Severe Traumatic Brain Injury Traumatic brain injury (TBI) is a serious neurological disorder, and the complexity of its treatment has long plagued the medical community. TBI not only leads to immediate loss of neurological function in patients, but also causes long-term tis...

Simultaneous, Cortex-Wide Dynamics of Up to 1 Million Neurons Reveal Unbounded Scaling of Dimensionality with Neuron Number

Medicine, Basic Medical Sciences, Neurology, Life Sciences, Cell Biology, Bioengineering, Biophysics,
cortex dynamics   neurons   dimensionality scaling   neural computation   neural activity   spontaneous behavior   neural ensembles  

Simultaneously Recording Up to a Million Neurons’ Cortical Dynamics Reveals Unbounded Scaling of Neuronal Quantity and Dimensionality Summary This scientific report titled “Simultaneously Recording Up to a Million Neurons’ Cortical Dynamics Reveals Unbounded Scaling of Neuronal Quantity and Dimensionality,” published in the journal Neuron (Volume 1...

Distinct Ultrastructural Phenotypes of Glial and Neuronal Alpha-Synuclein Inclusions in Multiple System Atrophy

Medicine, Rheumatology and Immunology, Basic Medical Sciences, Neurology,
multiple system atrophy   glial cells   neurons   alpha-synuclein   ultrastructure   pathology   human brain  

Different Ultrastructural Phenotypes of α-Synuclein Inclusions in Glia and Neurons in Brain Regions of Multiple System Atrophy (MSA) Introduction Multiple System Atrophy (MSA) is a severe neurodegenerative disease characterized by abnormal accumulation of α-Synuclein (α-Syn) in specific brain regions, forming pathological inclusions that primarily ...

Cognitive representations of intracranial self-stimulation of midbrain dopamine neurons depend on stimulation frequency

Medicine, Psychiatry, Neurology, Life Sciences, Cell Biology, Biochemistry, Genetics,
dopamine   neurons   self-stimulation   cognitive representations   stimulation frequency  

This paper reports a study on the cognitive representation of intracranial self-stimulation (ICSS) of midbrain dopamine neurons. The authors aimed to answer why rats work to obtain ICSS, i.e., how the pulsatile activation of dopamine neurons is represented in the brain. Research Background: The pulsatile activation of dopamine neurons is typically ...