Single-Nucleus Sequencing Reveals Enriched Expression of Genetic Risk Factors in ALS-Sensitive Neurons

Medicine, Basic Medical Sciences, Geriatrics, Neurology, Life Sciences, Biochemistry, Genetics,
single-nucleus sequencing   ALS   neurons   genetic risk factors   transcriptomics  

Publication of a New Study on ALS Neurodegeneration in 《Nature Aging》 Throughout human history, numerous mysterious diseases have posed significant challenges for scientific research. Among these, Amyotrophic Lateral Sclerosis (ALS), a progressive neurodegenerative disease, is known for the gradual loss of muscle function and disability it causes. ...

Neuritogenic Glycosaminoglycan Hydrogels Promote Functional Recovery After Severe Traumatic Brain Injury

Chemistry, Polymer Chemistry, Medicinal Chemistry, Materials Science, Organic Polymeric Materials, Medicine, Neurology, Life Sciences, Bioengineering,
neuritogenic   glycosaminoglycan   hydrogel   traumatic brain injury   functional recovery   cell adhesion   neurons  

Neuritogenic Glycosaminoglycan Hydrogels Promote Functional Recovery After Severe Traumatic Brain Injury Traumatic brain injury (TBI) is a serious neurological disorder, and the complexity of its treatment has long plagued the medical community. TBI not only leads to immediate loss of neurological function in patients, but also causes long-term tis...

Simultaneous, Cortex-Wide Dynamics of Up to 1 Million Neurons Reveal Unbounded Scaling of Dimensionality with Neuron Number

Medicine, Basic Medical Sciences, Neurology, Life Sciences, Cell Biology, Bioengineering, Biophysics,
cortex dynamics   neurons   dimensionality scaling   neural computation   neural activity   spontaneous behavior   neural ensembles  

Simultaneously Recording Up to a Million Neurons’ Cortical Dynamics Reveals Unbounded Scaling of Neuronal Quantity and Dimensionality Summary This scientific report titled “Simultaneously Recording Up to a Million Neurons’ Cortical Dynamics Reveals Unbounded Scaling of Neuronal Quantity and Dimensionality,” published in the journal Neuron (Volume 1...

Distinct Ultrastructural Phenotypes of Glial and Neuronal Alpha-Synuclein Inclusions in Multiple System Atrophy

Medicine, Rheumatology and Immunology, Basic Medical Sciences, Neurology,
multiple system atrophy   glial cells   neurons   alpha-synuclein   ultrastructure   pathology   human brain  

Different Ultrastructural Phenotypes of α-Synuclein Inclusions in Glia and Neurons in Brain Regions of Multiple System Atrophy (MSA) Introduction Multiple System Atrophy (MSA) is a severe neurodegenerative disease characterized by abnormal accumulation of α-Synuclein (α-Syn) in specific brain regions, forming pathological inclusions that primarily ...

Cognitive representations of intracranial self-stimulation of midbrain dopamine neurons depend on stimulation frequency

Medicine, Psychiatry, Neurology, Life Sciences, Cell Biology, Biochemistry, Genetics,
dopamine   neurons   self-stimulation   cognitive representations   stimulation frequency  

This paper reports a study on the cognitive representation of intracranial self-stimulation (ICSS) of midbrain dopamine neurons. The authors aimed to answer why rats work to obtain ICSS, i.e., how the pulsatile activation of dopamine neurons is represented in the brain. Research Background: The pulsatile activation of dopamine neurons is typically ...