A Multicellular Mechanochemical Model to Investigate Tumor Microenvironment Remodeling and Pre-Metastatic Niche Formation

Medicine, Oncology, Life Sciences, Cell Biology, Bioengineering,
Tumor Microenvironment   Pre-Metastatic Niche   Computational Modeling   Epithelial-Mesenchymal Transition   Tumor Cells   Kupffer Cells   Stellate Cells  

Colorectal Cancer (CRC) is one of the leading causes of cancer-related deaths in the United States, with liver metastasis being a common occurrence. Before tumor metastasis, the formation of the Pre-Metastatic Niche (PMN) is a critical process. PMN involves the activation of key liver-resident cells, including fibroblast-like stellate cells and mac...

Reactive Oxygen Species Regulation by NCF1 Governs Ferroptosis Susceptibility of Kupffer Cells to MASH

Medicine, Hepatobiliary System, Life Sciences, Cell Biology, Biochemistry, Immunology,
Reactive Oxygen Species   NCF1   Kupffer Cells   Iron Homeostasis   Ferroptosis   MASH   Lipid Peroxidation  

NCF1 Regulates Reactive Oxygen Species Vulnerability to Ferroptosis in Kupffer Cells and Its Impact on MASH Introduction Metabolic dysfunction-associated steatotic liver disease (MASLD), formerly known as non-alcoholic fatty liver disease (NAFLD), has a global prevalence of up to 25.2% and is a leading cause of chronic liver disease in adults and c...