Reactive Oxygen Species Regulation by NCF1 Governs Ferroptosis Susceptibility of Kupffer Cells to MASH

Medicine, Hepatobiliary System, Life Sciences, Cell Biology, Biochemistry, Immunology,
Reactive Oxygen Species   NCF1   Kupffer Cells   Iron Homeostasis   Ferroptosis   MASH   Lipid Peroxidation  

NCF1 Regulates Reactive Oxygen Species Vulnerability to Ferroptosis in Kupffer Cells and Its Impact on MASH Introduction Metabolic dysfunction-associated steatotic liver disease (MASLD), formerly known as non-alcoholic fatty liver disease (NAFLD), has a global prevalence of up to 25.2% and is a leading cause of chronic liver disease in adults and c...

Targeted Activation of Ferroptosis in Colorectal Cancer via LGR4 Targeting Overcomes Acquired Drug Resistance

Chemistry, Medicinal Chemistry, Medicine, Oncology, Life Sciences, Cell Biology, Biochemistry,
Colorectal Cancer   Ferroptosis   Acquired Drug Resistance   LGR4 Targeting   WNT Signaling Pathway  

Overcoming Acquired Resistance in Colorectal Cancer by Targeting LGR4 Research Background: Acquired drug resistance is a major obstacle in cancer treatment and a leading cause of cancer-related deaths. However, the mechanisms of resistance are diverse, and how to specifically target resistant cancer cells remains a significant clinical challenge. A...