Multiplex Cerebrospinal Fluid Proteomics Identifies Biomarkers for Diagnosis and Prediction of Alzheimer's Disease

Medicine, Medical Laboratory Science, Neurology, Medical Imaging, Life Sciences, Cell Biology,
Alzheimer's Disease   Cerebrospinal Fluid   Proteomics   Biomarkers   Diagnosis   Prediction  

Cerebrospinal Fluid Proteomics Study for Diagnosis and Prediction of Alzheimer’s Disease Background and Research Objectives Alzheimer’s disease (AD) is a neurodegenerative disease that leads to memory loss and cognitive decline, and currently, there is no effective cure globally. Traditionally, the pathological features of AD include β-amyloid (Aβ)...

Tandem mass spectrum prediction for small molecules using graph transformers

Chemistry, Analytical Chemistry, Computational Chemistry, Information Science, Artificial Intelligence,
Mass spectrometry   Graph transformer   Small molecules   Fragmentation patterns   Prediction  

This is a paper about MassFormer, a graph transformer model for small molecule mass spectrometry prediction. This research addresses the problem of molecular identification in mass spectrometry data and proposes a novel deep learning approach to predict mass spectra of small molecules. Background: Mass spectrometry (MS) is an analytical technique w...