Integrated Electrophysiological and Genomic Profiles of Single Cells Reveal Spiking Tumor Cells in Human Glioma

Medicine, Neurology, Oncology, Life Sciences, Cell Biology, Genetics,
Single-cell analysis   Glioma   Electrophysiology   Genomics   SCRAM algorithm  

Integration of Electrophysiological and Genomic Analysis Reveals Tumor Cells Capable of Generating Action Potentials in Human Gliomas Background and Research Objectives Gliomas are the most common malignant tumors in the central nervous system, with approximately 20,000 new cases annually. These tumors include two subtypes: isocitrate dehydrogenase...

Identification of a clinically efficacious CAR T cell subset in diffuse large B cell lymphoma by dynamic multidimensional single-cell profiling

Identification of a clinically efficacious CAR T cell subset in diffuse large B cell lymphoma by dynamic multidimensional single-cell profiling

Medicine, Rheumatology and Immunology, Oncology, Life Sciences, Immunology,
CAR T cells   Diffuse large B cell lymphoma   Single-cell analysis   Cell function   Clinical response  

Utilizing Dynamic Single-Cell Analysis to Discover a Clinically Effective Chimeric Antigen Receptor T-Cell Subset for Treating Diffuse Large B-Cell Lymphoma Research Background Chimeric antigen receptor (CAR) T-cell therapy has been proven to be an effective treatment for B-cell malignancies. However, it remains challenging to predict individual cl...