Targeting the Glucocorticoid Receptor-CCR8 Axis Mediated Bone Marrow T Cell Sequestration Enhances Infiltration of Anti-Tumor T Cells in Intracranial Cancers
Research Targeting Glucocorticoid Receptor-CCR8 Axis Mediated Bone Marrow T Cell Sequestration to Enhance Anti-tumor T Cell Infiltration in Intracranial Cancer Background Brain tumors, especially glioblastomas (GBMs), show significant resistance to immune checkpoint blockade therapy, partly due to limited T cell infiltration into tumors. GBMs accou...