From Bedside to Bench: New Insights in Epilepsy-Associated Tumors Based on Recent Classification Updates and Animal Models on Brain Tumor Networks

Medicine, Neurology, Neurosurgery, Medical Imaging, Oncology,
low-grade neuroepithelial tumors   epilepsy   in utero electroporation   mouse model   neuronal activity   brain tumors   neuro-oncology  

Latest Research on Epilepsy-Associated Tumors: Classification and Animal Models Background Epilepsy is a common neurological disorder, and some patients are accompanied by brain tumors, particularly low-grade neuroepithelial tumors (LGNTs). These tumors typically grow slowly but are highly associated with drug-resistant epilepsy. Although research ...

Targeting the Glucocorticoid Receptor-CCR8 Axis Mediated Bone Marrow T Cell Sequestration Enhances Infiltration of Anti-Tumor T Cells in Intracranial Cancers

Medicine, Rheumatology and Immunology, Neurology, Oncology, Life Sciences, Immunology,
brain tumors   anti-tumor immunity   T cell redistribution   glucocorticoid receptor   CCR8  

Research Targeting Glucocorticoid Receptor-CCR8 Axis Mediated Bone Marrow T Cell Sequestration to Enhance Anti-tumor T Cell Infiltration in Intracranial Cancer Background Brain tumors, especially glioblastomas (GBMs), show significant resistance to immune checkpoint blockade therapy, partly due to limited T cell infiltration into tumors. GBMs accou...