Targeting the Glucocorticoid Receptor-CCR8 Axis Mediated Bone Marrow T Cell Sequestration Enhances Infiltration of Anti-Tumor T Cells in Intracranial Cancers

Medicine, Rheumatology and Immunology, Neurology, Oncology, Life Sciences, Immunology,
brain tumors   anti-tumor immunity   T cell redistribution   glucocorticoid receptor   CCR8  

Research Targeting Glucocorticoid Receptor-CCR8 Axis Mediated Bone Marrow T Cell Sequestration to Enhance Anti-tumor T Cell Infiltration in Intracranial Cancer Background Brain tumors, especially glioblastomas (GBMs), show significant resistance to immune checkpoint blockade therapy, partly due to limited T cell infiltration into tumors. GBMs accou...

Exportin 1 governs the immunosuppressive functions of myeloid-derived suppressor cells in tumors through Erk1/2 nuclear export

Medicine, Rheumatology and Immunology, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology,
tumor   myeloid-derived suppressor cells   Exportin 1   MAPK pathway   anti-tumor immunity  

Paper Report Research Background Myeloid-Derived Suppressor Cells (MDSCs) are a major driving force in tumor immune suppression. Understanding their mechanisms can provide new therapeutic targets to improve anti-tumor immunity, as the development and immunosuppressive function of these cells directly affect anti-tumor immune responses. In preclinic...

LRIG1 engages ligand VISTA and impairs tumor-specific CD8+ T cell responses

Medicine, Rheumatology and Immunology, Oncology, Life Sciences, Cell Biology, Immunology,
LRIG1   VISTA   tumor-specific   CD8+ T cells   immune checkpoint   anti-tumor immunity   immunotherapy  

Immunotherapy Checkpoint Inhibitors (ICIs, also known as immune checkpoint blockers) are a class of drugs that have achieved significant breakthroughs in cancer immunotherapy in recent years. These drugs mainly work by blocking Programmed Death Protein 1 (PD-1) and Cytotoxic T-lymphocyte-associated Protein 4 (CTLA-4), thereby activating anti-tumor ...