Low-dose IL-2 treatment rescues cognitive deficits by repairing the imbalance between Treg and Th17 cells at the middle Alzheimer's disease stage

Medicine, Rheumatology and Immunology, Neurology, Life Sciences, Immunology,
low-dose IL-2 treatment   Alzheimer's disease   cognitive deficits   Treg   Th17   immune imbalance  

Low-dose IL-2 treatment rescues cognitive deficits by repairing the imbalance between Treg and Th17 cells at the middle Alzheimer’s disease stage Background Alzheimer’s disease (AD) is an age-related neurodegenerative disorder characterized by neuronal damage, amyloid plaque deposition, and chronic inflammation in the central nervous system (CNS). ...

Lipid Droplet Accumulation Mediates Macrophage Survival and Treg Recruitment via the CCL20/CCR6 Axis in Human Hepatocellular Carcinoma

Medicine, Rheumatology and Immunology, Hepatobiliary System, Basic Medical Sciences, Oncology, Life Sciences, Biochemistry, Immunology,
lipid droplets   macrophage survival   CCL20   Treg   hepatocellular carcinoma  

Lipid Droplet Accumulation Mediates Macrophage Survival and Treg Recruitment in Human Hepatocellular Carcinoma via the CCL20/CCR6 Axis Background Macrophages are a major component of the tumor microenvironment (TME) and regulate the entire tumor process. In the TME, macrophages exhibit dynamic heterogeneity and plasticity, which affects their role ...