Neutrophils Physically Interact with Tumor Cells to Form a Signaling Niche Promoting Breast Cancer Aggressiveness

Medicine, Oncology, Life Sciences,
Neutrophils   Breast Cancer   Signaling Niche   Tumor Microenvironment   Single-Cell RNA Sequencing  

Academic Background Breast cancer is one of the most common malignant tumors among women worldwide, with a complex pathogenesis involving interactions among multiple cell types and signaling pathways. In recent years, the role of the tumor microenvironment (TME) in cancer progression has gradually gained attention. Neutrophils, as an essential comp...

Limitations in Next-Generation Sequencing-Based Genotyping of Breast Cancer Polygenic Risk Score Loci

Medicine, Medical Laboratory Science, Oncology, Life Sciences, Biochemistry, Genetics,
Next-Generation Sequencing   Breast Cancer   Polygenic Risk Score   Genotyping   Variant Allele Frequencies   Genetic Counseling   Bioinformatics  

Limitations of Next-Generation Sequencing-Based Genotyping for Breast Cancer Polygenic Risk Score Loci Background Introduction In the prediction of hereditary Breast Cancer (BC), Polygenic Risk Scores (PRSs) are increasingly being used as an important tool for individual risk prediction. The calculation of PRS relies on accurately reproducing varia...

Prognostic Value of Serial Postoperative Circulating Tumor DNA Assessment During Long-Term Follow-Up in Patients with Breast Cancer

Prognostic Value of Serial Postoperative Circulating Tumor DNA Assessment During Long-Term Follow-Up in Patients with Breast Cancer

Medicine, Medical Laboratory Science, Oncology, Life Sciences, Immunology,
Breast Cancer   Circulating Tumor DNA   Long-Term Follow-Up   Prognosis   Personalized Medicine  

Scientific Research Report Background Introduction Breast cancer is the most commonly diagnosed cancer worldwide among both men and women, and it is the leading cause of cancer-related deaths in women. The standard treatment for early-stage breast cancer usually involves surgery and (neo)adjuvant chemotherapy and/or endocrine therapy, aiming to eli...

Persistence and Enrichment of Dominant T Cell Clonotypes in Expanded Tumor-Infiltrating Lymphocytes of Breast Cancer

Medicine, Rheumatology and Immunology, Medical Laboratory Science, Oncology, Life Sciences, Immunology,
Tumor-Infiltrating Lymphocytes   Breast Cancer   T Cell Clonotypes   Rapid Expansion   Immunotherapy   Ex Vivo Expansion   Memory T Cells  

Research Report: Dominance and Persistence of T-Cell Clones in Tumor-Infiltrating Lymphocytes during Expansion in Breast Cancer Background Tumor-infiltrating lymphocytes (TILs) are lymphocytes that naturally infiltrate the tumor microenvironment and exhibit reactivity to the tumor. This subject is one of the most actively researched areas in tumor ...

Identification of Lineage-Specific Epigenetic Regulators FOXA1 and GRHL2 through Chromatin Accessibility Profiling in Breast Cancer Cell Lines

Medicine, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology,
Breast Cancer   Epigenetics   Chromatin Accessibility   FOXA1   GRHL2   Cell Lines   Heterogeneity  

Identification of Lineage-Specific Epigenetic Regulators FOXA1 and GRHL2 through Chromatin Accessibility Analysis of Breast Cancer Cell Lines Background Breast cancer is a highly heterogeneous disease currently classified clinically based on gene expression patterns, intrinsic molecular subtypes, and the expression of hormone receptors/human epider...

Adeno-Associated Virus-Mediated Trastuzumab Delivery to the Central Nervous System for Human Epidermal Growth Factor Receptor 2+ Brain Metastasis

Medicine, Neurology, Oncology, Life Sciences, Cell Biology, Biochemistry, Bioengineering, Immunology,
Adeno-Associated Virus   Trastuzumab   Central Nervous System   Brain Metastasis   Gene Therapy   Breast Cancer   HER2  

AAV-Mediated Trastuzumab Delivery to the Central Nervous System for EGFR2-Positive Brain Metastases Introduction In the treatment of breast cancer, tumors that are human epidermal growth factor receptor 2 (HER2) positive exhibit more aggressive characteristics, posing significant challenges for clinical treatment. Since the approval of trastuzumab ...