Bioactive MgO/MgCO3/Polycaprolactone Multi-Gradient Fibers Facilitate Peripheral Nerve Regeneration by Regulating Schwann Cell Function and Activating Wingless/Integrase-1 Signaling

Chemistry, Polymer Chemistry, Materials Chemistry, Materials Science, Metallic Materials, Medicine, Neurology,
magnesium   multi-gradient fibers   Schwann cells   Wnt signaling pathway   peripheral nerve regeneration  

Study on Peripheral Nerve Regeneration Based on Multi-Gradient MgO/MgCO₃/PCL Nanofiber Membranes Academic Background Peripheral nerve defects are a common and complex orthopedic issue in clinical practice, with limited efficacy of current treatments. The insufficient proliferation and dysfunction of Schwann cells within nerve scaffolds are key fact...

Lack of Dominant-Negative Activity for Tumor-Related ZNRF3 Missense Mutations at Endogenous Levels

Medicine, Gastroenterology, Oncology, Life Sciences, Cell Biology, Biochemistry,
ZNRF3   β-catenin signaling   missense mutations   tumor   Wnt signaling pathway  

Academic Background and Paper Introduction Background The Wnt/β-catenin signaling pathway is dysregulated in various cancers, particularly in colorectal and endometrial cancers. Abnormal activation of this pathway is often associated with mutations in tumor suppressor genes such as APC, AXIN1/2, and β-catenin itself. Additionally, RNF43 and ZNRF3, ...