Lack of Dominant-Negative Activity for Tumor-Related ZNRF3 Missense Mutations at Endogenous Levels

Medicine, Gastroenterology, Oncology, Life Sciences, Cell Biology, Biochemistry,
ZNRF3   β-catenin signaling   missense mutations   tumor   Wnt signaling pathway  

Academic Background and Paper Introduction Background The Wnt/β-catenin signaling pathway is dysregulated in various cancers, particularly in colorectal and endometrial cancers. Abnormal activation of this pathway is often associated with mutations in tumor suppressor genes such as APC, AXIN1/2, and β-catenin itself. Additionally, RNF43 and ZNRF3, ...