Bioactive MgO/MgCO3/Polycaprolactone Multi-Gradient Fibers Facilitate Peripheral Nerve Regeneration by Regulating Schwann Cell Function and Activating Wingless/Integrase-1 Signaling

Chemistry, Polymer Chemistry, Materials Chemistry, Materials Science, Metallic Materials, Medicine, Neurology,
magnesium   multi-gradient fibers   Schwann cells   Wnt signaling pathway   peripheral nerve regeneration  

Study on Peripheral Nerve Regeneration Based on Multi-Gradient MgO/MgCO₃/PCL Nanofiber Membranes Academic Background Peripheral nerve defects are a common and complex orthopedic issue in clinical practice, with limited efficacy of current treatments. The insufficient proliferation and dysfunction of Schwann cells within nerve scaffolds are key fact...

Schwann cell derived pleiotrophin stimulates fibroblast proliferation and excessive collagen deposition in plexiform neurofibroma

Medicine, Medical Laboratory Science, Oral Sciences, Neurology, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology,
Schwann cells   pleiotrophin   fibroblasts   plexiform neurofibroma   collagen deposition   signaling pathway  

This study explores the interactions between Schwann cells and fibroblasts in neurofibromatosis type 1 (NF1) related plexiform neurofibroma (PNF). The background of the research is based on the high incidence of NF1, which affects about 1 in 3000 newborns worldwide and is associated with a series of unique clinical manifestations. PNF is a common p...