Poldip2 Mediates Brain Vascular Permeability by Regulating ROS-Mediated ZO-1 Phosphorylation and Localization at the Interendothelial Border

Medicine, Neurology, Life Sciences, Cell Biology,
blood–brain barrier   Poldip2   ZO-1   reactive oxygen species   brain endothelial cells  

POLDIP2 Regulates Cerebral Vascular Permeability by Modulating ROS-Mediated ZO-1 Phosphorylation and Localization Background The blood-brain barrier (BBB) is a critical component of the central nervous system (CNS), composed of brain endothelial cells, astrocytes, pericytes, and neurons. Brain endothelial cells form a continuous physical barrier th...

N-acetylglucosaminyltransferase V drives colorectal cancer metastasis by facilitating ZO-1 ubiquitination and degradation

N-acetylglucosaminyltransferase V drives colorectal cancer metastasis by facilitating ZO-1 ubiquitination and degradation

Medicine, Oncology, Life Sciences, Cell Biology, Biochemistry,
colorectal cancer   metastasis   ZO-1   EMT   glycosylation   MGAT5  

In a recent study published in “Cancer Cell International,” Yueping Zhan and others explored the role of N-acetylglucosaminyltransferase V (MGAT5) in colorectal cancer (CRC) and its mechanism in promoting cancer cell metastasis. The publication of this paper is driven by the urgent need to study CRC due to its high mortality and metastatic characte...