CYP19A1 Regulates Chemoresistance in Colorectal Cancer Through Modulation of Estrogen Biosynthesis and Mitochondrial Function

CYP19A1 Regulates Chemoresistance in Colorectal Cancer through Modulation of Estrogen Biosynthesis and Mitochondrial Function Background Colorectal cancer (CRC) is one of the leading causes of cancer-related mortality worldwide. Despite significant advances in early detection and treatment strategies, chemoresistance remains a major obstacle to eff...

FOXC1-Mediated Serine Metabolism Reprogramming Enhances Colorectal Cancer Growth and 5-FU Resistance

FOXC1-Mediated Serine Metabolism Reprogramming Enhances Colorectal Cancer Growth and 5-FU Resistance Background Colorectal cancer (CRC) is the third most common cancer globally and the second leading cause of cancer-related deaths. Although surgical resection and adjuvant chemotherapy are the primary treatments for CRC, tumor development and chemot...

MALDI Imaging Combined with Two-Photon Microscopy Reveals Local Differences in the Heterogeneity of Colorectal Cancer

MALDI Imaging Combined with Two-Photon Microscopy Reveals Local Differences in the Heterogeneity of Colorectal Cancer

Multimodal Imaging Study of the Tumor Microenvironment in Colorectal Cancer: Revealing Spatial Heterogeneity Academic Background Colorectal cancer (CRC) remains one of the leading causes of cancer-related mortality worldwide, with its complexity and heterogeneity posing significant challenges for treatment and prognosis prediction. The tumor microe...

Fusobacterium nucleatum Facilitates Anti-PD-1 Therapy in Microsatellite Stable Colorectal Cancer

Fusobacterium nucleatum Promotes Anti-PD-1 Therapy in Microsatellite-Stable Colorectal Cancer Background Introduction With the rise of immune checkpoint blockade (ICB) therapy, a new dawn has emerged in cancer treatment. However, despite the approval of PD-1 targeting drugs (e.g., Pembrolizumab) for certain types of colorectal cancer (CRC) patients...

N-acetylglucosaminyltransferase V drives colorectal cancer metastasis by facilitating ZO-1 ubiquitination and degradation

N-acetylglucosaminyltransferase V drives colorectal cancer metastasis by facilitating ZO-1 ubiquitination and degradation

In a recent study published in “Cancer Cell International,” Yueping Zhan and others explored the role of N-acetylglucosaminyltransferase V (MGAT5) in colorectal cancer (CRC) and its mechanism in promoting cancer cell metastasis. The publication of this paper is driven by the urgent need to study CRC due to its high mortality and metastatic characte...

Iron-(Fe3+)-Dependent Reactivation of Telomerase Drives Colorectal Cancers

Iron-(Fe3+)-Dependent Reactivation of Telomerase Drives Colorectal Cancers

Iron (Ferric Ion, Fe3+)-Dependent Telomerase Reactivation Drives Colorectal Cancer Development I. Research Background Colorectal Cancer (CRC) is the third most common cancer globally, involving both genetic and non-genetic factors in its pathogenesis. Existing research shows a significant association between high iron content, hereditary iron overl...

Patient-derived mini-colons enable long-term modeling of tumor–microenvironment complexity

Patient-derived mini-colons enable long-term modeling of tumor–microenvironment complexity

Long-term Model for Studying Tumor Microenvironment Complexity: Patient-derived Mini-colons Background: The interaction between tumors and their surrounding microenvironment has profound implications for cancer development and treatment. However, existing in vitro tumor models lack the ability to capture these complex interactions. To address this ...

Precision Colorectal Cancer Screening with Fecal Hemoglobin Concentration-Guided Intervals

Precise Colorectal Cancer Screening Based on Customized Intervals Using Fecal Hemoglobin Concentration Researchers: Amy Ming-Fang Yen, Yang-Ching Chen, Yu-Lin Ding, Wen-Zhu Qiu, Han-Mo Qiu, Tony Hsiu-Hsi Chen, Sam Li-Sheng Chen Academic Background Colorectal cancer (CRC) is the third most prevalent malignancy worldwide. In recent years, significant...