m6A mRNA Methylation in Brown Fat Regulates Systemic Insulin Sensitivity via an Inter-Organ Prostaglandin Signaling Axis Independent of UCP1

Medicine, Endocrinology, Life Sciences, Cell Biology, Biochemistry,
brown fat   m6A methylation   insulin sensitivity   prostaglandin   lipid metabolism   METTL14   signaling  

The Role of m6A mRNA Methylation in Adipose Tissue: A Breakthrough Discovery of Cross-Organ Prostaglandin Signaling Axis in Insulin Sensitivity Regulation Research Background and Motivation In recent years, the potential role of brown adipose tissue (BAT) in human metabolic regulation has attracted widespread attention. Known for its thermogenic pr...

Short-Term Cold Exposure Induces Persistent Epigenomic Memory in Brown Fat

Medicine, Basic Medical Sciences, Urology, Endocrinology, Life Sciences, Cell Biology, Biochemistry,
short-term cold exposure   epigenomic memory   brown fat   HDAC3   C/EBPβ   adaptive thermogenesis  

Short-term Cold Exposure Induces Persistent Epigenomic Memory in Brown Adipose Tissue Background Brown Adipose Tissue (BAT) is the primary non-shivering thermogenic organ in mammals that dissipates chemical energy as heat under cold stimuli. BAT is characterized by a high density of mitochondria containing Uncoupling Protein 1 (UCP1), which generat...