Research Report: The Role of Ketones in Cellular Physiology: Metabolic, Signaling, and Therapeutic Advances Academic Background For a long time, carbohydrate (CHO) intake has been considered a key factor in enhancing athletic performance during endurance exercise. The traditional view holds that a high-carbohydrate low-fat diet (HCLF) can increase ...
The Critical Role of Kindlin-3 in β2 Integrin Clustering Academic Background Neutrophils are the most abundant type of white blood cells in human blood, and their recruitment is essential for innate immunity and inflammatory responses. The initial and critical step in neutrophil recruitment is their adhesion to vascular endothelial cells, which dep...
D1R-5-HT2AR Uncoupling Alleviates Depressive Behaviors Through HDAC Signaling Research Background Major depressive disorder (MDD) is a globally prevalent and life-threatening mental illness, closely associated with poor physical health. Despite the availability of various treatments, including medications and psychotherapy, many patients exhibit po...
Analysis of the Molecular Recognition and Signal Transduction Mechanism of PRRP and PRRPR Research Background Neuropeptides, as the most abundant signaling molecules in the nervous system, have over 100 identified types and play critical roles in processes like metabolism, pain sensation, and reproduction. Among them, RF-amide neuropeptides are cha...
Differences in Signaling Requirements for Trophoblast Stem Cells between Humans and Marmosets Background and Research Motivation Embryo implantation and placenta formation are critical features of eutherian mammalian development. The trophoblast is a group of outer cells of the embryo that mediates the connection between the embryo and maternal tis...
The Role of m6A mRNA Methylation in Adipose Tissue: A Breakthrough Discovery of Cross-Organ Prostaglandin Signaling Axis in Insulin Sensitivity Regulation Research Background and Motivation In recent years, the potential role of brown adipose tissue (BAT) in human metabolic regulation has attracted widespread attention. Known for its thermogenic pr...
Differential Study of GPCR-G Protein Coupling Biosensors Background Introduction G protein-coupled receptors (GPCRs) are important molecules for transmembrane signal transduction, capable of selectively binding to heterotrimeric G proteins composed of Gα, Gβ, and Gγ subunits and regulating various intracellular signaling processes. Studying the fun...