Marmoset and Human Trophoblast Stem Cells Differ in Signaling Requirements and Recapitulate Divergent Modes of Trophoblast Invasion

Life Sciences, Cell Biology, Biochemistry, Genetics,
marmoset   trophoblast stem cells   signaling   placental development   trophoblast invasion  

Differences in Signaling Requirements for Trophoblast Stem Cells between Humans and Marmosets Background and Research Motivation Embryo implantation and placenta formation are critical features of eutherian mammalian development. The trophoblast is a group of outer cells of the embryo that mediates the connection between the embryo and maternal tis...

m6A mRNA Methylation in Brown Fat Regulates Systemic Insulin Sensitivity via an Inter-Organ Prostaglandin Signaling Axis Independent of UCP1

Medicine, Endocrinology, Life Sciences, Cell Biology, Biochemistry,
brown fat   m6A methylation   insulin sensitivity   prostaglandin   lipid metabolism   METTL14   signaling  

The Role of m6A mRNA Methylation in Adipose Tissue: A Breakthrough Discovery of Cross-Organ Prostaglandin Signaling Axis in Insulin Sensitivity Regulation Research Background and Motivation In recent years, the potential role of brown adipose tissue (BAT) in human metabolic regulation has attracted widespread attention. Known for its thermogenic pr...

Conformation- and Activation-Based BRET Sensors Differentially Report on GPCR-G Protein Coupling

Medicine, Life Sciences, Cell Biology, Biochemistry, Biophysics,
GPCR   G protein   signaling   BRET sensors   conformational changes   downstream effectors   drug discovery  

Differential Study of GPCR-G Protein Coupling Biosensors Background Introduction G protein-coupled receptors (GPCRs) are important molecules for transmembrane signal transduction, capable of selectively binding to heterotrimeric G proteins composed of Gα, Gβ, and Gγ subunits and regulating various intracellular signaling processes. Studying the fun...