m6A mRNA Methylation in Brown Fat Regulates Systemic Insulin Sensitivity via an Inter-Organ Prostaglandin Signaling Axis Independent of UCP1

Medicine, Endocrinology, Life Sciences, Cell Biology, Biochemistry,
brown fat   m6A methylation   insulin sensitivity   prostaglandin   lipid metabolism   METTL14   signaling  

The Role of m6A mRNA Methylation in Adipose Tissue: A Breakthrough Discovery of Cross-Organ Prostaglandin Signaling Axis in Insulin Sensitivity Regulation Research Background and Motivation In recent years, the potential role of brown adipose tissue (BAT) in human metabolic regulation has attracted widespread attention. Known for its thermogenic pr...

PKD1 mutant clones within cirrhotic livers inhibit steatohepatitis without promoting cancer

Medicine, Hepatobiliary System, Gastroenterology, Life Sciences, Biochemistry,
cirrhosis   PKD1 mutations   steatohepatitis   cancer inhibition   liver regeneration   mtor signaling   insulin sensitivity  

Background This paper aims to explore the function of somatic PKD1 mutations in cirrhosis and their impact on liver health without inducing cancer. The authors conducted this research because, although somatic mutations accumulate in non-malignant tissues and increase with age, it remains unclear whether these mutant clones are beneficial for organ...