SIRCLE Model Reveals Mechanisms of Phenotype Regulation in Renal Cancer

Medicine, Urology, Nephrology, Oncology,
multi-omics integration   phenotype regulation   machine learning   variational autoencoder   clear cell renal cell carcinoma   pancan   metabolism  

Executive Report on the Study of ccRCC Regulatory Mechanisms Using the SIRCLE Model Background Overview Clear Cell Renal Cell Carcinoma (ccRCC) is the most prevalent form of kidney cancer, accounting for 70% of renal malignancies. The development and progression of ccRCC involve intricate remodeling of the kidney epigenome, transcriptome, proteome,...

Systematic Multiomics Analysis and In Vitro Experiments Suggest ITGA5 as a Promising Therapeutic Target for CCRCC

Medicine, Nephrology, Oncology, Life Sciences, Cell Biology, Biochemistry, Genetics,
ITGA5   multiomics analysis   clear cell renal cell carcinoma   tumor microenvironment   therapeutic target  

Systematic Multi-Omics Analysis and In Vitro Experiments Suggest ITGA5 as a Potential Target for Clear Cell Renal Cell Carcinoma (ccRCC) Treatment Research Background and Motivation Clear cell renal cell carcinoma (ccRCC) is the most common subtype of renal cell carcinoma (RCC), accounting for about 75% of all kidney cancer cases. According to the ...