SPTLC2 Drives an EGFR-FAK-HBEGF Signaling Axis to Promote Ovarian Cancer Progression

Medicine, Obstetrics and Gynecology, Oncology,
ovarian cancer   EGFR signaling pathway   SPTLC2   tumor progression   metastasis   therapeutic target   cell proliferation  

SPTLC2 Drives an EGFR-FAK-HBEGF Signaling Axis to Promote Ovarian Cancer Progression Academic Background Ovarian cancer (OC) is one of the most lethal cancers in the female reproductive system, with complex pathogenesis and limited treatment options. The epidermal growth factor receptor (EGFR) signaling pathway is widely dysregulated in various can...

RBM39 as a Therapeutic Target in Acute Lymphoblastic Leukemia: Disruption of Cotranscriptional Splicing

Medicine, Hematology, Oncology, Life Sciences,
acute lymphoblastic leukemia   RBM39   cotranscriptional splicing   therapeutic target   splicing factor  

Research Summary Potential of Targeting RBM39 in High-Risk Acute Lymphoblastic Leukemia (B-ALL) Background Overview Acute Lymphoblastic Leukemia (ALL) is a hematological malignancy commonly diagnosed in children and young adults. Despite high remission rates through frontline chemotherapies, the long-term survival rate for patients with relapsed/re...

Systematic Multiomics Analysis and In Vitro Experiments Suggest ITGA5 as a Promising Therapeutic Target for CCRCC

Medicine, Nephrology, Oncology, Life Sciences, Cell Biology, Biochemistry, Genetics,
ITGA5   multiomics analysis   clear cell renal cell carcinoma   tumor microenvironment   therapeutic target  

Systematic Multi-Omics Analysis and In Vitro Experiments Suggest ITGA5 as a Potential Target for Clear Cell Renal Cell Carcinoma (ccRCC) Treatment Research Background and Motivation Clear cell renal cell carcinoma (ccRCC) is the most common subtype of renal cell carcinoma (RCC), accounting for about 75% of all kidney cancer cases. According to the ...

Retrospective Study of Claudin 18 Isoform 2 Prevalence and Prognostic Association in Gastric and Gastroesophageal Junction Adenocarcinoma

Medicine, Oncology, Life Sciences, Biochemistry, Immunology,
gastric cancer   gastroesophageal junction adenocarcinoma   claudin 18   biomarkers   prognosis   immunohistochemistry   therapeutic target  

Research Report on Claudin 18.2 in Gastric Cancer and Gastroesophageal Junction Adenocarcinoma Background Introduction Gastric cancer and gastroesophageal junction (G/GEJ) adenocarcinoma are major global health burdens. It is estimated that in 2020 alone, there were approximately 1.7 million new cases of gastric and esophageal cancers worldwide, wi...