Spatial Modeling Algorithms for Reactions and Transport in Biological Cells

Life Sciences, Cell Biology, Biochemistry, Bioengineering, Biophysics,
spatial modeling   reaction-transport   cell signaling networks   subcellular structures   finite element analysis   computational biology   membrane reactions  

Research on Spatial Modeling Algorithms for Cellular Signaling Reactions and Transport Background Biological cells achieve their functions through complex biochemical reaction networks. These networks exhibit significant spatiotemporal dynamics, with pronounced spatial compartmentalization across different regions and subcellular structures. Howeve...

Genome-aware annotation of CRISPR guides validates targets in variant cell lines and enhances discovery in screens

Medicine, Oncology, Life Sciences, Cell Biology, Bioengineering, Genetics,
CRISPR   genome annotation   bioinformatics   computational biology   software tool  

Genomic Medicine and Re-annotation of CRISPR Guides: Application and Validation of the EXORCISE Algorithm Academic Background The advent of CRISPR-Cas9 technology has revolutionized genetic screening, particularly in studying gene essentiality and chemo-genetic interactions. By designing guide RNAs (gRNAs) that target specific genes, the CRISPR-Cas...

Hierarchical Design of Pseudosymmetric Protein Nanocages

Chemistry, Nanoscience, Life Sciences, Biochemistry, Bioengineering,
protein design   nanomaterials   self-assembly   pseudosymmetry   computational biology  

Academic Background Protein self-assembly is a ubiquitous phenomenon in biological systems, performing a wide range of functions from structural support to biochemical regulation. Despite significant progress in protein design in recent years, existing self-assembling protein structures typically rely on strict symmetry, which limits their size and...