Multi-Omic Mapping of Human Pancreatic Islet Endoplasmic Reticulum and Cytokine Stress Responses Provides Genetic Insights into Type 2 Diabetes

Medicine, Endocrinology, Life Sciences, Cell Biology, Biochemistry, Genetics,
pancreatic islets   endoplasmic reticulum stress   cytokines   type 2 diabetes   genetic variants  

Background and Research Motivation Globally, Type 2 Diabetes (T2D) is a common metabolic disease characterized by the combined effects of genetic and environmental factors leading to dysfunction and/or cell death of pancreatic β-cells, resulting in insufficient insulin secretion. Based on findings from Genome-Wide Association Studies (GWAS), over 6...

Alleviating CB2-dependent ER stress and mitochondrial dysfunction improves chronic cerebral hypoperfusion-induced cognitive impairment

Medicine, Geriatrics, Neurology, Life Sciences, Cell Biology, Biochemistry, Immunology,
chronic cerebral hypoperfusion   cognitive impairment   endoplasmic reticulum stress   endocannabinoid system   fatty acid amide hydrolase   mitochondria  

Research Overview and Background With the acceleration of global aging, the incidence of ischemic cerebrovascular diseases is also rising significantly. Elderly people over 65 are particularly susceptible to cognitive decline caused by cerebral ischemia, making Chronic Cerebral Hypoperfusion (CCH) a major cause of cognitive impairment and Vascular ...