Multi-Omic Mapping of Human Pancreatic Islet Endoplasmic Reticulum and Cytokine Stress Responses Provides Genetic Insights into Type 2 Diabetes

Background and Research Motivation Globally, Type 2 Diabetes (T2D) is a common metabolic disease characterized by the combined effects of genetic and environmental factors leading to dysfunction and/or cell death of pancreatic β-cells, resulting in insufficient insulin secretion. Based on findings from Genome-Wide Association Studies (GWAS), over 6...