Development of an Engineered Direct Electron Transfer Enzyme for Continuous Levodopa Monitoring Background Parkinson’s Disease (PD) is a chronic neurodegenerative disease that affects millions of people worldwide. It is characterized by the loss of dopaminergic neurons in the substantia nigra and the presence of α-synuclein aggregations forming Lew...

Periodic and Aperiodic Components of Subthalamic Nucleus Activity Reflect Different Aspects of Motor Impairment in Parkinson’s Disease Background Parkinson’s disease (PD) is a common neurodegenerative disorder characterized by core symptoms such as bradykinesia, rigidity, and tremor. Although the neurophysiology of PD has been extensively studied, ...