Parkinson’s Disease Variant Detection and Disclosure: Comprehensive Report Background Parkinson’s Disease (PD) is a progressive neurodegenerative disorder primarily characterized by motor dysfunction and non-motor symptoms. Research has shown that at least seven genes (LRRK2, GBA1, PRKN, SNCA, PINK1, PARK7, VPS35) are directly related to the occurr...

Study on the Long-Term Risk of Dementia in Parkinson’s Disease Background Parkinson’s Disease (PD) is a common neurodegenerative disorder primarily characterized by motor dysfunction. However, cognitive decline and Parkinson’s disease dementia (PDD) are also significant non-motor symptoms of PD. Although dementia occurs in approximately 80% of PD p...

Scientific Paper News Report: Pathological Basis and Topological Properties of Structural Brain Networks in Parkinson’s Disease Patients Background and Research Objectives In Parkinson’s disease (PD), α-synuclein spreads between connected brain regions, leading to neuronal loss and brain network disruption. Using diffusion-weighted imaging (DWI), t...

Analysis of Trend Changes in Static Balance of Parkinson’s Disease Patients to Distinguish Drug States Introduction Maintaining static body balance is crucial for daily living, which requires coordination between different body segments. Any change or decline in balance ability increases the risk of falling. Patients with Parkinson’s disease (PD) e...

Application of Wearable Biofeedback Device in Gait Assessment for Parkinson’s Disease Patients: A Case Series Study Research Background Patients with Parkinson’s Disease (PD) often exhibit abnormal gait patterns, severely affecting their independence and quality of life. Gait abnormalities primarily manifest as reduced stride length, increased step...

Important Research Interpretation from “Journal of Neuroinflammation” 2024: The Impact of Park7/DJ-1 Deficiency on Microglial Activation Academic Background Parkinson’s Disease (PD) is the second most common neurodegenerative disease, characterized by the accumulation of α-synuclein and progressive loss of dopaminergic neurons. Aging is the primary...

Single-nucleus Multi-omics Analysis Reveals Age-related and Parkinson’s Disease-related Changes in Neuroglia in the Human Midbrain Research Background Age is a major risk factor for Parkinson’s Disease (PD). Although the significant role of age in PD onset is known, details about how age alters the gene expression and regulatory landscape of the br...

Patients with Parkinson’s Disease (PD) often experience gait impairments, which severely affect their quality of life. Previous studies have suggested that β-frequency (15-30 Hz) oscillatory activity in the basal ganglia may be associated with gait impairments, but the exact dynamics of these oscillations during the gait process remain unclear. Add...

Research on Quantitative Model for Freezing of Gait in Parkinson’s Patients Background Introduction Parkinson’s Disease (PD) is a common neurodegenerative disease, accompanied by complex motor disorders. In the later stages of Parkinson’s disease, the phenomenon of “Freezing of Gait” (FOG) becomes particularly prominent. FOG refers to a transient p...

Background and Research Motivation Parkinson’s Disease (PD) is a neurodegenerative disorder primarily affecting patients’ motor abilities, leading to tremors, bradykinesia, limb rigidity, and problems with gait and balance. These motor deficits significantly impact patients’ ability to live independently and their quality of life. Statistics predic...