Periodic and Aperiodic Components of Subthalamic Nucleus Activity Reflect Different Aspects of Motor Impairment in Parkinson's Disease

Medicine, Neurology,
Parkinson's disease   subthalamic nucleus   motor impairment   periodic activity   aperiodic activity   deep brain stimulation   levodopa  

Periodic and Aperiodic Components of Subthalamic Nucleus Activity Reflect Different Aspects of Motor Impairment in Parkinson’s Disease Background Parkinson’s disease (PD) is a common neurodegenerative disorder characterized by core symptoms such as bradykinesia, rigidity, and tremor. Although the neurophysiology of PD has been extensively studied, ...

Distinguishing Parkinsonian Rest Tremor from Voluntary Hand Movements through Subthalamic and Cortical Activity

Information Science, Artificial Intelligence, Medicine, Neurology, Medical Imaging, Life Sciences, Biophysics,
Parkinson’s disease   rest tremor   voluntary hand movements   brain activity   subthalamic nucleus   machine learning  

Parkinson’s disease (PD) is a common neurodegenerative disorder characterized mainly by resting tremor, bradykinesia, and rigidity. Deep Brain Stimulation (DBS) has been widely used to treat the motor symptoms of PD (Krauss et al., 2021). However, DBS treatment also has significant side effects, most of which are caused by the extension of stimulat...

Neurophysiological Features of STN LFP Underlying Sleep Fragmentation in Parkinson's Disease

Neurophysiological Features of STN LFP Underlying Sleep Fragmentation in Parkinson's Disease

Medicine, Neurology,
Parkinson's disease   local field potential   sleep fragmentation   subthalamic nucleus   beta oscillation  

Parkinson’s Disease (PD) is a neurodegenerative disease primarily characterized by dopaminergic neuron damage. Aside from causing motor disorders, over 80% of Parkinson’s disease patients also suffer from sleep disorders. Fragmented sleep is a common type of sleep disturbance among PD patients. It is associated not only with sleep maintenance insom...